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Additional infections with different serovars, the role of stress, age of the individual at the time of infection and many other factors are postulated but the details are unclear.Unfortunately, recently it became clear that Chlamydia could develop immune evasive mechanisms and produce immune-pathogenic Chlamydia antigens.In the female, infections with several serovars of Chlamydia trachomatis lead to cervicitis and urethritis as the primary sexually transmitted diseases (STDs).
Such immunosuppressive mechanisms have the potential to modify T response leading to Chlamydia latency or persistence, chronic host reaction and tissue damage.
Special concern is the multi drug resistant Chlamydia strains and the rapidly developing resistance to single drug regimens.
After the Chlamydia is eliminated, the T cells remain in the mucosa with memory of the infection preserved.
In case of a new infection these cells will promptly respond, shortening the duration of subsequent infections.
Several generations can live with the bacterium and to a certain extent inherit protecting antibodies. Whether stigmata of the infection surfaces in one or the other individual in subsequent generations or any pregnancies complicated are multifaceted issues. Surface antigens can change and thus evade recognition by T lymphocytes.
Such cases can lead to Chlamydia latency or persistence, inadequate chronic host reaction and tissue damage.Chlamydia can reach the upper compartment either by rapid surface growth following the first menstruation or by direct transfer using motile sperms.While the lower compartment can harbor asymptomatic Chlamydia infection for years, the upper compartment will respond to Chlamydia infection with a wide-ranging alteration in reproductive performance, hormonal changes and immunological reactions.In healthy individuals a fast and vigorous T response after a new infection will rapidly arrest Chlamydia replication, clear the infection, eliminate residual antigens and prevent the establishment of latent infection.In humans, there are wide ranging genetic differences in the degree of immune response.Chlamydia trachomatis has emerged recently as one of the most significant pathogens causing symptomatic or asymptomatic genital tract infections and infertility.Tags: Adult Dating, affair dating, sex dating